Endocrine Abstracts

Introduction: Pituitary adenomas are common, and their impact on visual function is often significant, given the intimate relationship between the anterior pituitary and the optic pathways. Ocular symptoms may be indicative. Compressive optic neuropathy and oculomotor paralysis present a diagnostic challenge. This report details four cases where ocular manifestations played an essential role in establishing the diagnosis of pituitary macroadenomas.Observ...

Introduction: We report a case of pupil sparing third nerve palsy caused by diabetes. Case Presentation: A 68-year-old woman consulted for acute left upper lid ptosis appeared since 2 days ago. The patient complained of blurred vision and periorbital pain. No history of head trauma or infection was reported. The patient has been diagnosed with type II diabetes mellitus and arterial hypertension since 15 years. Ophthalmological examination revealed comple...

Introduction: The diagnosis of insulinomas is made biochemically. However, proper localization of insulinomas is essential before surgery. Therefore, we aimed to evaluate the role of different imaging techniques in the localization of insulinomas. Case series: This case series include 10 patients with biochemically proven insulinomas. The age, gender, results of MRI, CT, EUS, are shown in Table-1. In imaging investigations, abdominal ultrasonography (AU)...

Introduction: Insulinoma is a rare neuroendocrine tumor with an incidence of 1 to 4 per million person-years. It is the most frequent endocrine tumor of the pancreas and is revealed by a spontaneous hypoglycemia. This study aimed to determine the clinical characteristics, diagnostic workup, and outcome of patients with insulinoma.Methods: This is a descriptive, retrospective study including patients with confirmed insulinoma collected over a 32-year peri...

Introduction: Multiple endocrine neoplasia type 2 is an inherited syndrome characterized by the characteristic combination of medullary thyroid cancer, pheochromocytoma and primary hyperparathyroidism. We report one case with phenotype-genotype mismatch.Observation: Patient A. T is 45 years of age with a family history of thyroid bone marrow cancer (CMT) and sister brain cancer, father colon cancer, with no personal history of disease. A 60 mm long-axis ...

Background and Aims: Cardiometabolic comorbidity is a well-established complication related to GH hypersecretion. Several studies have highlighted an increased cardiovascular risk in this population. The objective of the current work was to investigate the cardiovascular complications in Tunisian patients diagnosed with acromegaly.Patients and Method: We conducted a retrospective study that included all patients diagnosed with acromegaly who have been fo...

Introduction: Acromegaly is a chronic, slowly progressing disease caused in most cases by growth hormone (GH)- producing pituitary adenoma. This rare disorder is associated with a spectrum of various clinical manifestations and treatment outcomes differ between patients. The aim of this study was to evaluate the impact of adenoma size on comorbidities and biochemical status at the diagnosis of disease.Methods: This is a one-centre cohort study conducted ...

Background and Aims: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and distorted proportions. The objective of the current work was to investigate the clinical and demographic features of acromegaly in Mediterranean patients.Patients and Method: From 1997 to 2021, 29 patients with acromegaly were diagnosed and followed up...

Background and Aims: Acromegaly is an insidious disease related to hypersecretion of growth hormone (GH) that leads to several cardiovascular, respiratory, and metabolic comorbidities. The onset of dysmorphic body changes is one of the earliest signs of this condition. The objective of the current work was to describe the clinical manifestations of dysmorphic modifications characterizing Mediterranean patients diagnosed with acromegaly.Patients and Metho...

Introduction: Perrault syndrome (PS) is a rare disease characterized by the association of a premature ovarian failure (with primary or secondary amenorrhea) and a sensorineural deafness. In this context we report the case of three patients presenting the association of these two anomalies.Cases: We report the cases of three females, including two sisters from a consanguineous marriage, aged 21, 16 and 23 years, respectively. The two cardinal signs of th...